https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38039 Wed 28 Jul 2021 09:42:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42686 Wed 08 May 2024 12:01:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7584 Sat 24 Mar 2018 10:45:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15983 50% of asthma-related healthcare costs. New investigations into the pathogenesis of glucocorticoid resistance in severe asthma indicate that pulmonary macrophages may play central roles in promoting airway inflammation, particularly in asthma that is resistant to steroid therapy. Importantly, factors that are linked to the activation of pulmonary macrophages may contribute to glucocorticoid resistance and severe asthma. Here, we review recent advances in understanding the roles of pulmonary macrophages in the mechanisms of glucocorticoid resistance and the pathogenesis of severe asthma. We discuss the role of macrophage phenotype, infection, IFN-γ, LPS, associated signaling pathways, TNF-α, MIF, and other macrophage-associated factors. Understanding the pathogenesis of steroid-resistant severe asthma will contribute to the identification of optimal therapeutic strategies for the effective management of the disease.]]> Sat 24 Mar 2018 08:23:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20751 Sat 24 Mar 2018 08:00:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27093 Sat 24 Mar 2018 07:40:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22126 Sat 24 Mar 2018 07:09:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47479 Mon 23 Jan 2023 11:40:32 AEDT ]]>